Pitavastatin
Pitavastatin. Minimal CYP metabolism (primarily glucuronidation) → fewest drug interactions of any statin. Neutral to slightly favourable… Oral half-life 11 h.
Minimal CYP metabolism (primarily glucuronidation) → fewest drug interactions of any statin. Neutral to slightly favourable glycemic profile (versus the small dysglycemic tendency of other statins) — the main niche.
PK: THE WORST STRUCTURAL FAILURE IN ITS GROUP, AND IT CANNOT BE FIXED BY A BETTER SCALAR. The record under-predicts the peak by between 5.5x and 16x depending on which of its two source studies is used — and those two disagree with each other 2.8-fold on exposure — while matching one of them on exposure. The diagnostic is FORMULATION-INDEPENDENT and reproduced by both: the observed exposure-to-peak ratio is 2.99 and 2.90 hours while a one-compartment model at the stored half-life FORCES about 15.9, a 5.3-fold mismatch, because the stored volume is a TERMINAL volume being used as a central one for a drug whose mean residence time is about three hours. Either the peak under-prediction is accepted or the record is re-parameterised to an effective half-life near two hours, WHICH CANNOT BE SOURCED VERBATIM — so it is left as a design decision rather than patched. Class 6 is acquitted: the canonical volume is a true terminal volume consistent with the stored bioavailability. That bioavailability is nonetheless label-only and is ACTIVELY CONTRADICTED by this record own other reference, which puts pitavastatin at "60% OR GREATER". The absorption rate is a back-derivation solving to exactly 0.700 h where the cited abstract actual peak times are 0.63, 0.65 and 0.79 — provenance rather than magnitude, since the target is close to the true mean. The stored volume is also off by one from the canonical published figure, the same shape as atorvastatin 380-for-381. ABSORPTION-RATE PROVENANCE: this value was derived by inverting the one-compartment peak-time relation in 2026-05-26-wave25-ka-from-tmax.ts, whose header claimed every peak time was verbatim from a primary human study. ALL FORTY-FOUR ENTRIES HAVE NOW BEEN CHECKED AND TWENTY-EIGHT FAIL. This one fails because the cited abstract actual peak times are 0.63, 0.65 and 0.79 h and none is the 0.70 used. It is DISCLOSED RATHER THAN DELETED: a midpoint of a narrow range is usually inside the true spread, and removing it would fall back on the solver default of 1.0 per hour, which is worse for most of these records.
Pharmacokinetics
- Oral — t½ 11 h · F 51% · ka 6.74 h⁻¹ · Vd 147 L
Sources: PMID:15660968, PMID:26082816, PMID:16198653