Prasugrel

pharmacological · digestive · Oral

Prasugrel. Thienopyridine P2Y12 antagonist prodrug — hydrolyzed in intestine + activated by CYP3A4/2B6 to the active R-138727 metabolite. Faster + more consistent…

Thienopyridine P2Y12 antagonist prodrug — hydrolyzed in intestine + activated by CYP3A4/2B6 to the active R-138727 metabolite. Faster + more consistent activation than clopidogrel; higher bleeding risk. Contraindicated in stroke/TIA history due to hemorrhagic stroke signal.

Sources: PMID:25697420, PMID:19698014