Prednisolone

hormone · endocrine · digestive · Oral · IV

Prednisolone, a hormone. Active glucocorticoid — prednisone is reduced to prednisolone by hepatic 11β-HSD1. Direct prednisolone use bypasses the… Oral half-life 3 h.

Active glucocorticoid — prednisone is reduced to prednisolone by hepatic 11β-HSD1. Direct prednisolone use bypasses the activation step (preferred in liver dysfunction). ~4× cortisol potency. Same indications + adverse effect profile as prednisone.

Pharmacokinetics

• Oral — t½ 3 h · F 85% · Vd 50 L
• IV — t½ 3 h · F 100% · Vd 50 L

Sources: PMID:7915437