Pregabalin
Pregabalin. α2δ Ca²⁺-channel ligand (same target as gabapentin) — better-defined PK with linear absorption (no saturable transporter). Approved… Oral half-life 6 h.
α2δ Ca²⁺-channel ligand (same target as gabapentin) — better-defined PK with linear absorption (no saturable transporter). Approved for neuropathic pain, fibromyalgia, post-herpetic neuralgia, focal seizures. Schedule V (mild euphoria + abuse signal).
PK: real-PMID zero-content — the cited paper states none of the four values — but two of them are genuine and merely misattributed. Re-pointed to PMID:20147618, pooled across five healthy-volunteer studies, verbatim "Pregabalin oral bioavailability is approximately 90% and is independent of dose and frequency of administration" and "Pregabalin elimination half-life is approximately 6 hours"; the stored 6.3 h was a rounding of neither. ka 1.5 /h and V 35 L dropped; the 0.7 to 1.3 h beside the rate is a time to peak. EFFECT COMPARTMENT: A RAT VALUE THAT READ AS HUMAN. The rate is verbatim from a rat brain-microdialysis study — its own title says "in rats" — with the species field unset. Kept and declared; the paper itself reads the value as slow, which is the right qualitative shape for this drug.
Pharmacokinetics
- Oral — t½ 6 h · F 90%
Sources: PMID:20147618, PMID:23205518