Prochlorperazine
Prochlorperazine. Phenothiazine D2 antagonist — antiemetic via chemoreceptor trigger zone D2 blockade. Anti-dopaminergic side effects (EPS… Oral half-life 8 h.
Phenothiazine D2 antagonist — antiemetic via chemoreceptor trigger zone D2 blockade. Anti-dopaminergic side effects (EPS, akathisia, dystonia) limit chronic use. Common for migraine + chemotherapy nausea + vertigo.
PK: its source was an INTRAVENOUS-ONLY oncology study in 13 patients on concurrent doxorubicin, so it could not yield an oral bioavailability on any grounds — and the stored F of 0.13 matches that COHORT SIZE, the patient-count collision shape. V 1240 L is untraceable; that paper states 2254 L per square metre, about 3900 L, while the healthy-volunteer study gives 12.9 L/kg after intravenous dosing. The stored 7 h corresponds to NO MEASURED PHASE — the sources give 9 h intravenously, 8 h orally, 18 h at steady state and a 21.9 h terminal phase — so the two routes now carry their own measured values. F 0.147 is the only verbatim primary bioavailability that exists and it comes from six elderly women, which is recorded rather than hidden; it is stored because deleting it would leave the resolver default overstating oral exposure sixfold. DOCUMENTED HYSTERESIS WITH NO EFFECT COMPARTMENT: "maximal drug effects occurred 2-4 h after peak plasma drug concentrations". No equilibration value is derived from that range. The rectal route is removed as having zero support anywhere.
Pharmacokinetics
- Oral — t½ 8 h · F 15% · Vd 900 L
- IV — t½ 9 h · F 100% · Vd 900 L
Sources: PMID:1768559, PMID:1553856