Propofol
Propofol. Lipid-soluble GABA-A positive allosteric modulator + glycine receptor potentiation. Workhorse IV induction + maintenance anesthetic; rapid… IV half-life 4 h.
Lipid-soluble GABA-A positive allosteric modulator + glycine receptor potentiation. Workhorse IV induction + maintenance anesthetic; rapid onset (~30 sec) and short duration. Hypotension via vasodilation; "propofol infusion syndrome" (lactic acidosis, rhabdomyolysis) at prolonged high-dose ICU sedation.
DOSE: THE STORED FIGURE WAS THE RAW PER-WEIGHT NUMBER, NOT A DOSE — 1–2.5 mg/kg induction, entered as flat milligrams. The dose unit enumeration has no weight-based member and the solver never weight-scales a dose, so THE ONLY REPRESENTABLE FORM IS THE SEVENTY-KILOGRAM EQUIVALENT, and that is what this record now carries. I TESTED THE OBJECTION THAT THIS READS A SCHEMA GAP AS A DATA DEFECT AND THE DISTINCTION IS CLEAN: vancomycin stores the seventy-kilogram equivalent of its weight-based regimen and is CORRECT, meropenem is genuinely flat-dosed and is CORRECT, and eleven records store the raw per-weight number and are WRONG BY ROUGHLY SEVENTY-FOLD. Both of my priors on the two correct records were wrong. EFFECT COMPARTMENT: CLASS 13 — VERBATIM-CORRECT AND STILL WRONG BY FOUR AND A HALF FOLD. The stored rate is genuinely in its cited paper, but it is one parameter of "a TWO COMPARTMENT effect-site model with a keo of 0.102 min-1, ke12 of 0.121 min-1 and ke21 of 0.172 min-1", fitted in fourteen ADOLESCENTS on a scoliosis wake-up test — a structure the solver cannot represent, so lifting one of its three constants into a single-compartment slot is not the same quantity. IT IMPLIED AN EQUILIBRATION HALF-TIME OF 6.8 MINUTES FOR A DRUG WHOSE OWN LITERATURE OBSERVES PEAK EFFECT AT 1.6. The canonical adult fit replaces it and states its own validation in the same sentence. THE PHARMACOKINETIC ROW IS SEPARATELY BROKEN AND IS NOT REPAIRED HERE BECAUSE NO VERBATIM REPLACEMENT EXISTS: the volume is the euthyroid CONTROL arm of a THYROID-DISEASE study, a steady-state volume from a multi-compartment fit, and the stored half-life APPEARS NOWHERE IN THAT ABSTRACT. The pair asserts a clearance 4.4-fold below the accepted figure, and the same paper own infusion data confirm it independently — at its stated rate the model predicts a steady-state concentration four-fold above what that paper observed. A volume consistent with the stored half-life would be around 866 L, which is not a propofol volume on any reading, so the half-life is the guilty parameter and it has no published one-compartment counterpart. LOGGED.
Pharmacokinetics
- IV — t½ 4 h · F 100% · Vd 196 L
Sources: PMID:9661573, PMID:7838996, PMID:10360845