Psilocin

other · nervous · Oral

Psilocin. Active dephosphorylated metabolite of psilocybin (a prodrug, hydrolyzed by alkaline phosphatase to psilocin in vivo). A 5-HT2A… Oral half-life 1.8 h.

Active dephosphorylated metabolite of psilocybin (a prodrug, hydrolyzed by alkaline phosphatase to psilocin in vivo). A 5-HT2A receptor agonist — the classical psychedelic mechanism — with additional 5-HT2C and 5-HT1A activity. Risks: HPPD, anxiety / "bad trip," transient blood-pressure and heart-rate elevation; Schedule I.

PubChem CID 4980. The active metabolite of the registry's psilocybin entry. PK: Holze 2023 (PMID:36507738) verbatim psilocin elimination half-life "1.8 hours (1.7-2.0)" for 15 mg oral psilocybin in healthy participants.

Pharmacokinetics

• Oral — t½ 1.8 h

Sources: PMID:36507738, PMID:36049313