Quinine

alkaloid · immune-hematologic · Oral

Quinine, an alkaloid. Cinchona-bark alkaloid; antimalarial via heme polymerization inhibition in Plasmodium digestive vacuole. Cardiac… Oral half-life 11 h.

Cinchona-bark alkaloid; antimalarial via heme polymerization inhibition in Plasmodium digestive vacuole. Cardiac sodium-channel blockade explains the QT prolongation + nocturnal-leg-cramps off-label use.

Sources: PMID:12695533, PMID:8471402