Reserpine

alkaloid · nervous · cardiovascular · Oral

Reserpine, an alkaloid. Indole alkaloid from Rauwolfia serpentina. Irreversible VMAT2 inhibitor — depletes catecholamines and serotonin from… Oral half-life 33 h.

Indole alkaloid from Rauwolfia serpentina. Irreversible VMAT2 inhibitor — depletes catecholamines and serotonin from synaptic vesicles. Antihypertensive (largely abandoned for SSRI-precipitated depression risk); historical interest for the "monoamine hypothesis" of depression.