Rivastigmine

nootropic · nervous · Oral · Transdermal

Rivastigmine, a nootropic. Pseudo-irreversible carbamate inhibitor of both AChE AND BuChE — broader cholinergic effect than donepezil. Approved… Oral half-life 1.5 h.

Pseudo-irreversible carbamate inhibitor of both AChE AND BuChE — broader cholinergic effect than donepezil. Approved for Alzheimer's and Parkinson's dementia; transdermal patch reduces GI burden vs oral.

Pharmacokinetics

• Oral — t½ 1.5 h · F 35% · Vd 130 L
• Transdermal — t½ 3.4 h · F 100% · Vd 130 L

Sources: PMID:9737824