Rizatriptan
Rizatriptan. 5-HT1B/1D agonist — second-generation triptan; faster oral onset and higher receptor potency than sumatriptan. Orally… Oral half-life 1.8 h.
5-HT1B/1D agonist — second-generation triptan; faster oral onset and higher receptor potency than sumatriptan. Orally disintegrating tablet useful when migraine causes nausea. MAO-A substrate (dose adjust with propranolol).
PK: F 0.47 is verbatim and stands. ka 2 duplicates the record own stored half-life AND is arithmetically refuted — with the published time to peak of 1.6 h the implied absorption rate is about 0.95 /h, so the stored value is roughly twice too fast. V 110 L appears in no abstract; the primary gives a steady-state volume of 140 L alongside a 1.8 h half-life in one sentence. A sex-stratified origin for 110 is plausible but unverified and is therefore recorded as a hypothesis only, not acted on. EFFECT DECOUPLING WORTH NOTING: the plasma curve is essentially cleared by 8-10 h while 24-hour sustained pain freedom is the standard registration endpoint, and no published effect-compartment value exists for this drug, so none is stored.
Pharmacokinetics
- Oral — t½ 1.8 h · F 47% · Vd 140 L
Sources: PMID:11680669, PMID:8991488