Rocuronium

pharmacological · nervous · IV

Rocuronium. Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh receptor antagonist at the motor endplate. Workhorse… IV half-life 1.5 h.

Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh receptor antagonist at the motor endplate. Workhorse intubating muscle relaxant; rapid onset (~60 sec). Reversal with sugammadex (encapsulating agent) or neostigmine + glycopyrrolate.

DOSE CORRECTED FROM A PER-KILOGRAM VALUE STORED AS AN ABSOLUTE ONE. The IV block read {"min":0.6,"max":1.2,"typical":1,"unit":"mg"} — those are mg/kg, not mg, and `doses` admits only absolute mg/g/mcg/IU, so occupancy was being judged at about a seventieth of a real dose. Label verbatim: "Tracheal intubation : Recommended initial dose is 0.6 mg/kg". At the 70 kg reference that is 42-84 mg, typical 42 mg — ARITHMETIC, mg/kg x 70 kg. Source: Rocuronium Bromide Injection, DailyMed set id 04c9812d-5aa3-4949-ad02-c618028f1bb0, v1 published 2026-08-17. The label’s own recommended initial dose is the typical; 1.2 mg/kg is its rapid-sequence upper end. FOUND BY `occupancy.ts`: nothing reading one field at a time can see this, because every number in the row is individually well-formed.