RU-58841
RU-58841. Non-steroidal AR antagonist originally developed by Roussel-Uclaf (acne). Applied topically for androgenetic alopecia — locally antagonises AR → reduces…
Non-steroidal AR antagonist originally developed by Roussel-Uclaf (acne). Applied topically for androgenetic alopecia — locally antagonises AR → reduces DHT-driven follicular miniaturisation. Designed for rapid systemic clearance — any plasma fraction metabolised quickly to reduce systemic antiandrogen effects. Clinical development halted in late 1990s; research + off-label use continues.