S14G-Humanin
S14G-Humanin, a peptide. The Ser14->Gly analogue of the mitochondrial-derived peptide humanin, introduced as the more potent form: PMID:11739234 verbatim describes…
The Ser14->Gly analogue of the mitochondrial-derived peptide humanin, introduced as the more potent form: PMID:11739234 verbatim describes "the effects of [Gly(14)]-humanin, a more potent humanin analogue" against the parent, which the same abstract calls "a very recently discovered 24 amino acid linear polypeptide". Reported cytoprotective actions are anti-apoptotic and anti-oxidative rather than receptor-occupancy: STAT3 and ERK1/2 activation in rat renal ischaemia-reperfusion (PMID:42672739) and NF-kB suppression in mouse acute lung injury (PMID:38054825). In human myotubes it blunts glucocorticoid signalling — PMID:41732124 verbatim, "HNG co-treatment with DEXA preserved myotube area (p < 0.001), blunted DEXA-induced STAT3 activation (p = 0.027), but had no effect on fusion index or E3 ligase mRNA levels." NO HUMAN ADMINISTRATION EXISTS.
NO MOLECULAR WEIGHT IS STORED, ON PURPOSE. PubChem has no entry for this analogue: `S14G-humanin`, `S14G humanin`, `HNG`, `humanin G` and `Gly14-humanin` each return PUGREST.NotFound (queried 2026-09-26). The parent humanin is CID 16131438 (C119H204N34O32S2, 2687.2) and THAT MASS BELONGS TO THE PARENT, NOT THIS RECORD — storing it here would be a wrong-molecule mass of the kind HYGIENE R10 rejects. A Ser->Gly substitution is -CH2O, so ~2657.2 is arithmetically implied, but that is a derivation from a formula no abstract states for this peptide, so it is left unstored rather than authored under R4. IDENTITY IS SOURCED: PMID:42672739 ties three of the aliases together in one phrase, "the effects of S14G-humanin (humanin G, HNG)". DISTINCT FROM `humanin`, which is already in this catalog — the potency claim in PMID:11739234 is the warrant for a separate record rather than an alias. A PAPER THAT LOOKS LIKE HUMAN EXPOSURE AND IS NOT: PMID:41975304 measures endogenous "Humanin (HN)" in older women as an exercise biomarker; that is the parent peptide as an analyte, not administration of this analogue, and must not be read as human exposure data. DOSES AS PUBLISHED, none of them human and none stored: "HNG (2 mg/kg, i.v.) was administered 10 min before reperfusion" in rats (PMID:42672739); "followed by an intraperitoneal injection of 3 and 6 mg/kg HNG" in mice (PMID:38054825); "[Gly(14)]-Humanin (1000 pmol 5 microl(-1) i.c.v.)" in mice (PMID:11739234). The myotube work used a concentration, not a dose — "exposed to 10 microM DEXA +/-10 microM HNG" (PMID:41732124).
Sources: PMID:42672739, PMID:41732124, PMID:11739234, PMID:38054825