Saffron

adaptogen · nervous · Oral

Saffron, an adaptogen. Stigma extract; crocin + safranal + picrocrocin are the named actives. Multiple meta-analyses report antidepressant effect… Oral half-life 8 h.

Stigma extract; crocin + safranal + picrocrocin are the named actives. Multiple meta-analyses report antidepressant effect comparable to fluoxetine 20 mg in mild-to-moderate depression. SSRI-like serotonin reuptake modulation suggested; mechanism not fully resolved.