Salidroside

adaptogen · nervous · digestive · Oral

Salidroside, an adaptogen. Tyrosol glucoside — the principal active adaptogen of Rhodiola rosea. Crosses BBB (brain-to-plasma AUC ~0.2 in rats).… Oral half-life 1.2 h.

Tyrosol glucoside — the principal active adaptogen of Rhodiola rosea. Crosses BBB (brain-to-plasma AUC ~0.2 in rats). Mechanisms: PI3K/AKT activation, AMPK induction, Nrf2-mediated antioxidant response, NF-κB inhibition, and modest monoamine-oxidase inhibition contributing to the fast-onset antifatigue / antidepressant signal. Rat PK: Cmax ~6–12 µg/mL after 25 mg/kg oral at Tmax 0.5 h, t½ 1.5–2.5 h, absolute bioavailability 51–98% depending on dose (Fan 2020 review). Hepatic UGT-mediated glucuronidation dominant elimination route. No definitive human PK published.

Pharmacokinetics

• Oral — t½ 1.2 h · F 32%

Sources: PMID:32603893, PMID:24043591