Selank
Selank, a peptide. N-terminal addition of Thr-Lys-Pro-Arg (tuftsin) + C-terminal Pro-Gly-Pro stabilisation. Enhances BDNF expression, modulates enkephalin-degrading…
N-terminal addition of Thr-Lys-Pro-Arg (tuftsin) + C-terminal Pro-Gly-Pro stabilisation. Enhances BDNF expression, modulates enkephalin-degrading enzymes, and activates GABA-A without direct benzodiazepine-site binding. Anxiolytic without sedation or addiction potential (Russian trial data).
Heptapeptide (TKPRPGP) — bioavailability data (IN F ≈ 0.06, SC F ≈ 1.0) and PK parameters are inferred from animal (rodent) biodegradation and tissue-distribution models (Zolotarev 2006, PMID:16637290; Ashmarin 2008, PMID:18695718) as primary human PK data is unavailable. Plasma clearance is rapid (plasma t½ ~6–12 min); effective duration in humans (24+ hours) far exceeds plasma residence due to downstream BDNF and enkephalin pathway modulation (PD, not PK).
Related compounds
- Semax — synergistic
Sources: PMID:16637290, PMID:18695718, PMID:29787664, PMID:18454096