Selegiline

pharmacological · nervous · Oral · Transdermal

Selegiline. Selective MAO-B inhibitor at low oral doses (5–10 mg) → preserves dopamine (MAO-B substrate) without the tyramine interaction of non-selective MAOIs.…

Selective MAO-B inhibitor at low oral doses (5–10 mg) → preserves dopamine (MAO-B substrate) without the tyramine interaction of non-selective MAOIs. Metabolises to L-methamphetamine + L-amphetamine (active metabolites). Used as Parkinson's adjunct to reduce on/off fluctuations. Transdermal patch at ≥9 mg loses MAO-B selectivity → requires tyramine-free diet.

Sources: PMID:2515726, PMID:8785378, PMID:17715422, PMID:2505797