Silybin

flavonoid · digestive · Oral · IV

Silybin, a flavonoid. Principal flavonolignan in the silymarin complex from Silybum marianum. Hepatoprotective via free-radical scavenging… Oral half-life 6 h.

Principal flavonolignan in the silymarin complex from Silybum marianum. Hepatoprotective via free-radical scavenging, hepatocyte membrane stabilization, inhibition of CYP3A4/P-gp (clinical DDI risk), and Amanita phalloides poisoning antidote (IV silibinin = Legalon SIL). Mixed silybin A + B diastereomers in extracts.

Loram 2007 + others — oral F is very low (~1-4%); silybin-phytosome (Siliphos) and silibinin meglumine improve absorption ~10x.

Pharmacokinetics

• Oral — t½ 6 h · F 4% · Vd 100 L
• IV — t½ 6 h · F 100% · Vd 100 L

Sources: PMID:17125289