Silymarin
Silymarin, a flavonoid. Mixture of six flavonolignans (silibinin A/B, isosilibinin A/B, silicristin, silidianin) plus taxifolin. Silibinin is the… Oral half-life 7 h.
Mixture of six flavonolignans (silibinin A/B, isosilibinin A/B, silicristin, silidianin) plus taxifolin. Silibinin is the principal active isomer. Hepatoprotection via multiple mechanisms: glutathione restoration, Kupffer-cell NF-κB suppression, membrane stabilisation against Amanita phalloidin uptake (competitive OATP1B3 inhibition — the basis of Legalon Rx use in death-cap poisoning), direct scavenging of ROS, and mild stellate-cell anti-fibrotic activity. Poor oral F (~1–5% unconjugated) due to extensive phase II glucuronidation and enterohepatic recycling; phytosome formulations substantially improve absorption.
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.
Pharmacokinetics
- Oral — t½ 7 h · F 3% · ka 0.7922 h⁻¹
Sources: PMID:32065376