SLU-PP-332
SLU-PP-332. Synthetic acylhydrazone agonist of the estrogen-related receptors, a family of orphan nuclear receptors that sit upstream of mitochondrial biogenesis and…
Synthetic acylhydrazone agonist of the estrogen-related receptors, a family of orphan nuclear receptors that sit upstream of mitochondrial biogenesis and oxidative metabolism. It activates all three (ERR-alpha, -beta, -gamma) with the greatest potency at ERR-alpha, reproducing part of the transcriptional program exercise induces — which is why it is described as an exercise mimetic, and why its published effects are aerobic performance, mitochondrial function and metabolic phenotype in obese and aged mice rather than anything receptor-selective.
PubChem CID 5338394 (C18H14N2O2), CAS 303760-60-3 — 4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide. A small molecule, not a peptide, despite the company it keeps on peptide vendor lists. NO EC50 IS STORED: `SLU-PP-332 EC50` returns zero hits and the only potency statement in any abstract is qualitative — it "targets all three ERRs but has the highest potency for ERRalpha" (PMID:36988910). Authoring a receptor_occupancy row would need a number, so none is authored. NO DOSE: none of the ten abstracts states mg/kg; what they state is species and schedule, 21-month-old mice for 8 weeks (PMID:37717940), diet-induced-obese and ob/ob mice (PMID:37739806), a pressure-overload heart-failure model (PMID:37961903). THE ROUTE IS THE FINDING. PMID:41421047 says the compound "improves aerobic performance in mice but lacks oral bioavailability" and is given "when administered intraperitoneally"; PO is listed because that is the form sold, and the record says the literature contradicts it rather than quietly modelling an absorbed oral dose. PMID:36988910 offers only "has sufficient pharmacokinetic properties to be used as an in vivo chemical tool", which is an assertion with no parameter. REGISTRY HAZARD: SLU-PP-915 is a DIFFERENT compound from the same programme that IS orally bioavailable; that property must not migrate onto this record, which states the opposite. Human liver S9 and microsome metabolite identifications exist (PMID:41688415 reporting 22 metabolites, PMID:41588687 reporting 9 — the two labs disagree on the count) and are metabolite IDs, not kinetics.
Sources: PMID:36988910, PMID:37739806, PMID:41421047, PMID:37717940