Sufentanil
Sufentanil. Synthetic μ-opioid agonist — phenylpiperidine class with ~10× fentanyl potency. Used in anesthesia + obstetric epidural / spinal… IV half-life 2.7 h.
Synthetic μ-opioid agonist — phenylpiperidine class with ~10× fentanyl potency. Used in anesthesia + obstetric epidural / spinal analgesia. CYP3A4 substrate.
PK: THE RECORD TOOK THE WRONG VOLUME FROM A SENTENCE THAT OFFERS BOTH. Its citation states "Vd beta was 2.9 +/- 0.2 1/kg, Vdss 1.7 +/- 0.2 1/kg and total plasma clearance 12.7 +/- 0.8 ml X kg-1 X min-1 (935 +/- 50 ml/min)", and the steady-state volume was stored where THE TERMINAL VOLUME IS THE ONE THAT BELONGS WITH A TERMINAL HALF-LIFE. The consequence was a clearance 1.84x below that paper own figure, and the severity was visible without any arithmetic: the model retained 88% of its initial concentration at thirty minutes where the same paper reports "98% of the administered dose having left the plasma within 30 min". THE EFFECT-SITE CONSTANT WAS ALSO DERIVED FROM A NARRATIVE REVIEW rather than measured — that review says only "each with equilibration half-lives of about 6 min", and computing a rate from an approximation violates the verbatim rule twice over. The primary measurement exists and is close: "The half-time of blood-brain equilibration (T1/2Keo) was not statistically different between sufentanil and fentanyl (6.2 +/- 2.8 vs. 6.6 +/- 1.7 min)". The stored value was 3.3% from the truth, which is recorded as a near-miss. Its phantom absorption rate on an intravenous route is removed, and an intramuscular route declared with no parameters goes with it. DOSE: THE STORED FIGURE WAS THE RAW PER-WEIGHT NUMBER, NOT A DOSE — 0.1–30 mcg/kg, entered as flat milligrams. The dose unit enumeration has no weight-based member and the solver never weight-scales a dose, so THE ONLY REPRESENTABLE FORM IS THE SEVENTY-KILOGRAM EQUIVALENT, and that is what this record now carries. I TESTED THE OBJECTION THAT THIS READS A SCHEMA GAP AS A DATA DEFECT AND THE DISTINCTION IS CLEAN: vancomycin stores the seventy-kilogram equivalent of its weight-based regimen and is CORRECT, meropenem is genuinely flat-dosed and is CORRECT, and eleven records store the raw per-weight number and are WRONG BY ROUGHLY SEVENTY-FOLD. Both of my priors on the two correct records were wrong. EFFECT COMPARTMENT: THE OLD VALUE WAS DERIVED FROM A NARRATIVE REVIEW WITH NO SUBJECTS, violating the verbatim rule twice over — it was COMPUTED, and computed from an "about". The primary measurement exists in a paper reporting both this drug and fentanyl in one sentence, WHICH IS THE MOST DANGEROUS SHAPE IN THIS LITERATURE AND I CHECKED IT: the two records differ in value and in citation, so no transplant has occurred. THE STORED VALUE WAS ONLY 3.3 PERCENT FROM THE TRUTH, which is recorded as a near-miss so the correction is not mistaken for a large one. A LEAK WAS FOUND NEXT DOOR WHILE CHECKING: fentanyl own rate is annotated as a rat tail-flick endpoint with its species field UNSET, so it counts among the records claiming a fitted human value while being an animal one.
Pharmacokinetics
- IV — t½ 2.7 h · F 100% · Vd 203 L
Sources: PMID:6238552, PMID:2137997, PMID:1670913