Sulforaphane

polyphenol · digestive · Oral

Sulforaphane, a polyphenol. Released from glucoraphanin by the enzyme myrosinase (from plant or gut microbiota) upon chewing/processing —… Oral half-life 1.8 h.

Released from glucoraphanin by the enzyme myrosinase (from plant or gut microbiota) upon chewing/processing — sulforaphane is the active isothiocyanate. Potent Nrf2 activator: alkylates KEAP1 cysteines → disinhibits Nrf2 → transcription of phase II detoxification / antioxidant genes (glutathione synthesis, NQO1, HO-1). Also HDAC inhibitor at high concentrations.

Pharmacokinetics

• Oral — t½ 1.8 h · F 74% · ka 0.937 h⁻¹

Sources: PMID:21816223, PMID:18950181