Sumatriptan Succinate (specifically)
Sumatriptan Succinate (specifically). Sumatriptan as the succinate salt — sublingual + injectable formulations use this salt for… Subcutaneous half-life 2 h.
Sumatriptan as the succinate salt — sublingual + injectable formulations use this salt for solubility. Same 5-HT1B/1D agonism + cranial vasoconstriction as sumatriptan. Listed separately because the salt MW differs from free base for solubility-dependent dosing.
PK: AN ABSORPTION RATE DERIVED WITH THE WRONG FORMULA, A HALF-LIFE FROM THE WRONG ROUTE, AND A DUPLICATE RECORD. Its authoring script states the method in its own comment — "ka derived from Tmax 12 min via ka ~ ln2/(Tmax/2) ~ 7/hr" — WHICH IS NOT THE BATEMAN RELATION THIS SOLVER USES; it implies a 28.8 minute peak against that citation verbatim twelve minutes. Every authoring script was grepped and that formula appears ONCE, only here, so the error did not spread; the sibling record had its own subcutaneous rate removed for the same defect and this one survived. The half-life is verbatim but it is the INTRANASAL value, and the script own override REPLACED THIS RECORD ORIGINAL, CORRECT SUBCUTANEOUS 2 h WITH IT — a documented regression, now reversed. Bioavailability moves from a range interior to the verbatim endpoint of "96-100%", cited at last to the paper that actually states both it and the volume. THE ROW IS NEVERTHELESS UNREPRESENTABLE AND THAT IS RECORDED RATHER THAN TUNED AWAY: verbatim exposure over peak is 1.427 hours against a floor of 2.885 even at the corrected half-life, 2.02x below what any parameter choice can produce, and a second paper names the reason — "The decay curve ... includes a large distribution component". A SALT-VERSUS-BASE MISMATCH IS ALSO LOGGED, and it runs OPPOSITE to the hydroxychloroquine shape: the mass is the succinate while the doses are free base, which does not overstate the dose and is inert until an interaction edge or occupancy site is authored.
Pharmacokinetics
- Subcutaneous — t½ 2 h · F 96% · Vd 170 L
Sources: PMID:28597922, PMID:27613076, PMID:7768259, PMID:19925626