Tacrolimus (topical)

topical · musculoskeletal · integumentary · immune-hematologic · Transdermal

Tacrolimus (topical), a topical compound. Topical calcineurin inhibitor — binds FKBP-12 → blocks calcineurin-dependent T cell activation… Transdermal half-life 10 h.

Topical calcineurin inhibitor — binds FKBP-12 → blocks calcineurin-dependent T cell activation locally in skin. Steroid-sparing for atopic dermatitis, especially face / eyelid where steroid atrophy is concerning. FDA black-box for theoretical lymphoma risk; epidemiologic signal weak.