Tasimelteon

sleep · nervous · Oral

Tasimelteon, a sleep compound. Melatonin MT1/MT2 dual receptor agonist with ~2× preference for MT2 (the SCN circadian receptor). FDA approved… Oral half-life 1.3 h.

Melatonin MT1/MT2 dual receptor agonist with ~2× preference for MT2 (the SCN circadian receptor). FDA approved for non-24-hour sleep-wake disorder in totally blind patients.

Pharmacokinetics

• Oral — t½ 1.3 h · F 38% · Vd 42.7 L

Sources: PMID:25658956, PMID:19054552