Thymosin β4
Thymosin β4, a peptide. Ubiquitous G-actin-sequestering protein — 5–15% of total intracellular protein in many cell types. Controls actin polymerisation /…
Ubiquitous G-actin-sequestering protein — 5–15% of total intracellular protein in many cell types. Controls actin polymerisation / depolymerisation dynamics critical to cell migration. Promotes angiogenesis via upregulation of VEGF-A + FGF-2. Phase 2 trials for corneal / skin / cardiac repair have been positive; full-length molecule is longer-acting than TB-500 fragment.
Related compounds
- TB-500 — synergistic