Tenofovir Alafenamide

pharmacological · renal · musculoskeletal · immune-hematologic · Oral

Tenofovir Alafenamide. Newer prodrug of tenofovir — preferential cleavage by lymphocyte cathepsin A → higher intracellular tenofovir-DP with much lower plasma…

Newer prodrug of tenofovir — preferential cleavage by lymphocyte cathepsin A → higher intracellular tenofovir-DP with much lower plasma tenofovir vs TDF. Reduced renal + bone toxicity. Replaces TDF in modern combination ART regimens.

Sources: PMID:27216057, PMID:34703277, PMID:32539288