Tesofensine

pharmacological · nervous · Oral

Tesofensine. Triple monoamine reuptake inhibitor (DAT + NET + SERT). Originally trialed for Alzheimer + Parkinson, abandoned, then resurrected… Oral half-life 9.2 d.

Triple monoamine reuptake inhibitor (DAT + NET + SERT). Originally trialed for Alzheimer + Parkinson, abandoned, then resurrected for obesity — Phase 2 weight loss ~10% at 6 months. Approved in Mexico / Argentina for obesity; not FDA-approved.