THC

alkaloid · nervous · Oral · Inhaled · Transdermal · Sublingual

THC, an alkaloid. Primary psychoactive phytocannabinoid — partial CB1 agonist (CNS) + CB2 partial agonist (peripheral). CB1 in nucleus accumbens… Oral half-life 25 h.

Primary psychoactive phytocannabinoid — partial CB1 agonist (CNS) + CB2 partial agonist (peripheral). CB1 in nucleus accumbens / PFC drives the euphoria + cognitive effects; CB1 in brainstem is sparse, explaining the very low overdose-respiratory-depression risk.

Sources: PMID:17641667, PMID:25311884