Theophylline
Theophylline, an alkaloid. Non-selective adenosine A1/A2A/A2B antagonist + non-selective PDE inhibitor (PDE3, PDE4 primarily). Drives airway… Oral half-life 8 h.
Non-selective adenosine A1/A2A/A2B antagonist + non-selective PDE inhibitor (PDE3, PDE4 primarily). Drives airway smooth-muscle relaxation and anti-inflammatory histone-deacetylase-2 activation at lower doses. Metabolised primarily by CYP1A2 + CYP3A4 — highly interaction-prone (fluvoroquinolones, macrolides, cimetidine all raise levels).
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.
Pharmacokinetics
- Oral — t½ 8 h · F 96%
- IV — t½ 8 h · F 100%
Related compounds
- Caffeine — caution
Sources: PMID:6370542