Tiotropium

pharmacological · respiratory · Inhaled

Tiotropium. Long-acting muscarinic antagonist (LAMA) — quaternary ammonium derivative of ipratropium with M3 receptor kinetic selectivity… Inhaled half-life 27 h.

Long-acting muscarinic antagonist (LAMA) — quaternary ammonium derivative of ipratropium with M3 receptor kinetic selectivity (slow dissociation from M3 vs M2 → 24h dosing). Cornerstone COPD maintenance therapy; also approved for severe asthma.

Sources: PMID:19653626