Urolithin A

polyphenol · digestive · Oral

Urolithin A, a polyphenol. Formed by gut microbiota from dietary ellagitannins (pomegranate, walnut, raspberry) via a multi-step conversion to… Oral half-life 20 h.

Formed by gut microbiota from dietary ellagitannins (pomegranate, walnut, raspberry) via a multi-step conversion to urolithin A. Critical caveat: only ~30–40% of adults are 'urolithin producers' depending on gut composition — explaining the pomegranate trial heterogeneity and the rationale for direct UA supplementation. Potent mitophagy inducer — selectively removes damaged mitochondria via PINK1-Parkin and BNIP3 pathways. Preclinical lifespan extension + muscle-function data.

Pharmacokinetics

• Oral — t½ 20 h · Vd 84 L

Related compounds

• Ellagic Acid — synergistic

Sources: PMID:32694802