Vecuronium
Vecuronium. Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh antagonist. Intermediate-acting (~30 min). Hepatic +… IV half-life 2.2 h.
Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh antagonist. Intermediate-acting (~30 min). Hepatic + biliary clearance — accumulates in liver failure.
PK: ITS CITATION IS AN EFFECT-COMPARTMENT PAPER THAT STATES NO VOLUME, NO HALF-LIFE AND NO CLEARANCE. Neither stored value appears in any source I could find, and the half-life sits between the two real ones like a midpoint. The stored pair implied a clearance BELOW EVEN THE CHOLESTASIS GROUP of this record own other reference, which reports the healthy value falling "from 4.30 +/- 1.56 ml min-1 kg-1 ... to 2.36 +/- 0.80" — the record asserted 1.98, i.e. 2.2x under the healthy figure. Everything moves to one adult abstract at this record exact dose whose three numbers are mutually consistent to five percent: "total volume of distribution (791 +/- 303 versus 919 +/- 360 mL/kg IBW), plasma clearance (4.65 +/- 0.89 versus 5.02 +/- 1.13 mL.min-1.kg IBW-1), and elimination half-life (119 +/- 43 versus 133 +/- 57 min)", control arm. A CAVEAT IS STATED RATHER THAN BURIED: that volume is a terminal one, so the fix preserves EXPOSURE at the cost of the early peak, where the true central volume is some twenty times smaller — AND FOR A NEUROMUSCULAR BLOCKER THE ONSET PHASE IS THE CLINICALLY LIVE ONE. Its effect-site constant is verified verbatim and untouched. DOSE: THE STORED FIGURE WAS THE RAW PER-WEIGHT NUMBER, NOT A DOSE — 0.08–0.1 mg/kg intubating, entered as flat milligrams. The dose unit enumeration has no weight-based member and the solver never weight-scales a dose, so THE ONLY REPRESENTABLE FORM IS THE SEVENTY-KILOGRAM EQUIVALENT, and that is what this record now carries. I TESTED THE OBJECTION THAT THIS READS A SCHEMA GAP AS A DATA DEFECT AND THE DISTINCTION IS CLEAN: vancomycin stores the seventy-kilogram equivalent of its weight-based regimen and is CORRECT, meropenem is genuinely flat-dosed and is CORRECT, and eleven records store the raw per-weight number and are WRONG BY ROUGHLY SEVENTY-FOLD. Both of my priors on the two correct records were wrong.
Pharmacokinetics
- IV — t½ 2.2 h · F 100% · Vd 64.3 L
Sources: PMID:2875724, PMID:7486041, PMID:1348166