Withanoside IV
Withanoside IV, a terpenoid. Glycosylated withanolide — aglycone is withanolide-A linked to a sugar moiety. The dominant glycowithanolide in standardized…
Glycosylated withanolide — aglycone is withanolide-A linked to a sugar moiety. The dominant glycowithanolide in standardized "glycoside-rich" ashwagandha extracts (Shoden). Preclinical models show neurite-outgrowth and anxiolytic activity (likely after gut/hepatic hydrolysis to free withanolide-A). The clinical effect rationale of glycoside-standardized extracts is sustained downstream aglycone exposure.
Glycoside of withanolide-A; dominant glycowithanolide in Shoden-standardized extracts. PK not separately characterized in humans; effect likely transduced through aglycone after gut hydrolysis.