Yohimbine

alkaloid · nervous · Oral

Yohimbine, an alkaloid. α₂-adrenergic receptor antagonist — blocks the pre-synaptic α₂ autoreceptor that normally brakes noradrenaline release →… Oral half-life 0.6 h.

α₂-adrenergic receptor antagonist — blocks the pre-synaptic α₂ autoreceptor that normally brakes noradrenaline release → elevates sympathetic tone, noradrenaline, and lipolytic drive (particularly in subcutaneous adipose where α₂ density is high → the rationale for 'stubborn-fat' use). Also antagonises some 5-HT receptors at higher doses. Narrow safety window — supplements commonly contain higher-than-labelled concentrations.

Pharmacokinetics

• Oral — t½ 36 min · F 33% · Vd 350 L

Related compounds

• Caffeine — caution

Sources: PMID:2076728, PMID:7996470, PMID:8097957