Zolpidem

sleep · nervous · Oral · Sublingual

Zolpidem, a sleep compound. Non-benzodiazepine α1-selective GABA-A PAM (the α1 subunit drives hypnosis; avoiding α2/α3 minimises… Oral half-life 2.4 h.

Non-benzodiazepine α1-selective GABA-A PAM (the α1 subunit drives hypnosis; avoiding α2/α3 minimises anxiolytic/myorelaxant effects). Rapid onset + short t½ for sleep-onset indication.

Pharmacokinetics

• Oral — t½ 2.4 h · F 70% · ka 2.775 h⁻¹ · Vd 38 L

Sources: PMID:1684924, PMID:10454469, PMID:3198298