Zopiclone

sleep · nervous · Oral

Zopiclone, a sleep compound. Cyclopyrrolone GABA-A α1-preferring positive allosteric modulator. Sedative-hypnotic; ~5h half-life so longer-acting… Oral half-life 5 h.

Cyclopyrrolone GABA-A α1-preferring positive allosteric modulator. Sedative-hypnotic; ~5h half-life so longer-acting than zolpidem. Withdrawn in US (eszopiclone is the marketed S-enantiomer); used internationally.

Pharmacokinetics

• Oral — t½ 5 h · F 80% · Vd 100 L

Sources: PMID:8787948, PMID:6329982, PMID:9951403