Bone remodeling

signaling · musculoskeletal · endocrine

Bone remodeling. RANK/RANKL/OPG + PTH/Wnt-sclerostin + bisphosphonates. Signaling pathway. Bone remodeling balance: osteoclasts (resorption) + osteoblasts…

Modulators

• denosumab — inhibitor
• teriparatide — activator
• alendronate — inhibitor
• risedronate — inhibitor
• ibandronate — inhibitor
• zoledronate — inhibitor
• calcitonin — inhibitor

Sources: PMID:12748652, PMID:19671655