Immune checkpoint blockade

immune_innate · immune-hematologic

Immune checkpoint blockade. PD-1 / PD-L1 / CTLA-4. Innate immunity pathway. T-cell activation requires antigen recognition (TCR-MHC) + co-stimulation (CD28-B7) but is…

Modulators

• nivolumab — inhibitor
• pembrolizumab — inhibitor
• atezolizumab — inhibitor

Sources: PMID:22658127, PMID:20525992, PMID:22437870