JAK-STAT signaling

signaling · immune-hematologic

JAK-STAT signaling. Signaling pathway. Cytokine receptor → JAK → STAT → nuclear → transcription. Cytokine binding triggers receptor dimerization → JAK (1/2/3/TYK2)…

Modulators

• tofacitinib — inhibitor
• baricitinib — inhibitor
• upadacitinib — inhibitor
• ruxolitinib — inhibitor

Sources: PMID:29999544, PMID:25587654, PMID:28323260