NLRP3 inflammasome

immune_innate · immune-hematologic

NLRP3 inflammasome. pyroptosis + IL-1β. Innate immunity pathway. Multi-protein cytoplasmic complex activated by danger signals (urate crystals, cholesterol crystals…

Modulators

• allopurinol — inhibitor
• colchicine — inhibitor

Sources: PMID:20303873, PMID:30026524