PDE5 / NO-cGMP axis

signaling · cardiovascular · reproductive

PDE5 / NO-cGMP axis. erectile + pulmonary vascular. Signaling pathway. Nitric oxide → sGC → cGMP → PKG smooth-muscle relaxation cascade is the molecular basis of…

Modulators

• sildenafil — inhibitor
• tadalafil — inhibitor
• vardenafil — inhibitor
• riociguat — activator
• dipyridamole — inhibitor
• nitroglycerin — activator
• isosorbide-mononitrate — activator

Sources: PMID:17942972