Pyrimidine de novo synthesis + salvage

biosynthesis · immune-hematologic · digestive

Pyrimidine de novo synthesis + salvage. Biosynthesis pathway. De novo pyrimidine synthesis: carbamoyl-P (CPS2, cytosolic; distinct from urea-cycle CPS1) → orotate →…

Modulators

• methotrexate — inhibitor
• ump — substrate

Sources: PMID:32043431