Vasodilator pharmacology

signaling · cardiovascular

Vasodilator pharmacology. NO / sGC / endothelin / direct. Signaling pathway. Vascular tone arises from the balance of vasoconstrictors (endothelin-1, angiotensin II…

Modulators

• nitroglycerin — activator
• isosorbide-mononitrate — activator
• riociguat — activator
• bosentan — inhibitor
• macitentan — inhibitor
• hydralazine — activator
• sacubitril — inhibitor

Sources: PMID:2451132