Warfarin metabolism

drug_metabolism · cardiovascular · immune-hematologic

Warfarin metabolism. enantiomer-resolved. Drug metabolism pathway. Warfarin is a 1:1 racemate; the enantiomers clear via different CYPs. S-warfarin (3-5× more potent…

Modulators

• fluconazole — inhibitor
• amiodarone — inhibitor
• rifampin — activator
• cimetidine — inhibitor

Sources: PMID:19228618, PMID:1581537