Adenosine

nucleoside · cardiovascular · IV

Adenosine, a nucleoside. Endogenous signalling nucleoside acting at four GPCR subtypes: A1 (cardiac slowing, inhibition of NE release), A2A… IV half-life 0 h.

Endogenous signalling nucleoside acting at four GPCR subtypes: A1 (cardiac slowing, inhibition of NE release), A2A (vasodilation, wakefulness suppression — caffeine's principal target), A2B, A3. Accumulates with neural activity and is the presumed somnogen driving sleep pressure. Extremely short plasma t½ (seconds) — deaminated to inosine by adenosine deaminase.

Pharmacokinetics

• IV — t½ 0 min

Related compounds

• Caffeine — caution
• Dipyridamole — major
• PEAK ATP — synergistic

Sources: PMID:9690865, PMID:2184971