Alpha-Tocopherol

vitamin · digestive · Oral

Alpha-Tocopherol, a vitamin. Lipid-peroxyl-radical scavenger in cell membranes — donates H· from the chromanol hydroxyl to terminate lipid… Oral half-life 2.5 d.

Lipid-peroxyl-radical scavenger in cell membranes — donates H· from the chromanol hydroxyl to terminate lipid peroxidation chain reactions. Regenerated to active form by ascorbate and glutathione. α-Tocopherol is preferentially retained by hepatic α-TTP; other isoforms (γ, δ, tocotrienols) are largely excreted.

Pharmacokinetics

• Oral — t½ 2.5 d · F 30% · ka 0.1563 h⁻¹

Related compounds

• Warfarin / anticoagulants — caution
• Tocotrienols — caution

Sources: PMID:9537614, PMID:15911722, PMID:36145092