Tocotrienols
Tocotrienols, a vitamin. Tocotrienols differ from tocopherols by an unsaturated isoprenoid side chain, which gives better membrane penetration but lower affinity for…
Tocotrienols differ from tocopherols by an unsaturated isoprenoid side chain, which gives better membrane penetration but lower affinity for α-tocopherol transfer protein (α-TTP) — so plasma t½ is short (~3–5 h) vs α-tocopherol (~20 h). δ-Tocotrienol is the most bioactive isomer for HMG-CoA reductase suppression (post-translational degradation of the enzyme), lipoprotein(a) lowering, and NF-κB inhibition. Co-administration with α-tocopherol interferes with tocotrienol absorption — annatto-sourced (α-tocopherol-free) extracts are preferred.
PK: STRIPPED. THE ONLY HUMAN STUDY REPORTS EACH ISOMER SEPARATELY — δ-tocotrienol in the body of the abstract and then "Similar results of these parameters were reported for γ-tocotrienol, β-tocotrienol, α-tocotrienol" and three tocopherols — so there is no single species for a one-compartment curve to describe. THE VOLUME IN THAT ABSTRACT IS DIMENSIONALLY IMPOSSIBLE AS PRINTED, "volume of distribution (Vd/f, mg/h) 0.34", and the stored record used neither it nor the stated half-life: the abstract gives 2.74 and 2.68 h for δ-tocotrienol against a stored 4. The volume was the solver default wearing a citation.
Related compounds
- α-Tocopherol — caution
Sources: PMID:27493840