Calcium

mineral · digestive · musculoskeletal · Oral

Calcium, a mineral. Second messenger released from smooth/skeletal ER and mitochondria via ryanodine and IP3 receptors; binds calmodulin to activate downstream…

Second messenger released from smooth/skeletal ER and mitochondria via ryanodine and IP3 receptors; binds calmodulin to activate downstream kinases/phosphatases and contractile machinery. Active intestinal absorption via TRPV6 is calcitriol-dependent; paracellular absorption dominates at high intakes. Hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂) is the bone mineral matrix; bone is the dominant body pool.

Related compounds

• Magnesium — caution
• Iron — caution
• Iron Bisglycinate — caution
• Levothyroxine — caution
• Calcitriol — caution
• Vitamin D3 — synergistic

Sources: PMID:11444420, PMID:17507729, PMID:2816495